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2020
Innovations present in the primate interneuron repertoire
Krienen FM, Goldman M, Zhang Q, C H Del Rosario R, Florio M, Machold R, Saunders A, Levandowski K, Zaniewski H, Schuman B, Wu C, Lutservitz A, Mullally CD, Reed N, Bien E, Bortolin L, Fernandez-Otero M, Lin JD, Wysoker A, Nemesh J, Kulp D, Burns M, Tkachev V, Smith R, Walsh CA, Dimidschstein J, Rudy B, S Kean L, Berretta S, Fishell G, Feng G, McCarroll SA. Nature. 2020 Oct;586(7828):262-269. doi: 10.1038/s41586-020-2781-z. Epub 2020 Sep 30.
Opportunities and limitations of genetically modified nonhuman primate models for neuroscience research
Feng G, Jensen FE, Greely HT, Okano H, Treue S, Roberts AC, Fox JG, Caddick S, Poo MM, Newsome WT, Morrison JH. Proc Natl Acad Sci U S A. 2020 Sep 29;117(39):24022-24031. doi: 10.1073/pnas.2006515117. Epub 2020 Aug 19.
Viral manipulation of functionally distinct interneurons in mice, non-human primates and humans
Vormstein-Schneider D, Lin JD, Pelkey KA, Chittajallu R, Guo B, Arias-Garcia MA, Allaway K, Sakopoulos S, Schneider G, Stevenson O, Vergara J, Sharma J, Zhang Q, Franken TP, Smith J, Ibrahim LA, M Astro KJ, Sabri E, Huang S, Favuzzi E, Burbridge T, Xu Q, Guo L, Vogel I, Sanchez V, Saldi GA, Gorissen BL, Yuan X, Zaghloul KA, Devinsky O, Sabatini BL, Batista-Brito R, Reynolds J, Feng G, Fu Z, McBain CJ, Fishell G, Dimidschstein J. Nat Neurosci. 2020 Dec;23(12):1629-1636. doi: 10.1038/s41593-020-0692-9. Epub 2020 Aug 17.
The dawn of non-human primate models for neurodevelopmental disorders
Aida T, Feng G. Curr Opin Genet Dev. 2020 Dec;65:160-168. doi: 10.1016/j.gde.2020.05.040. Epub 2020 Jul 18.
Distinct subnetworks of the thalamic reticular nucleus
Li Y, Lopez-Huerta VG, Adiconis X, Levandowski K, Choi S, Simmons SK, Arias-Garcia MA, Guo B, Yao AY, Blosser TR, Wimmer RD, Aida T, Atamian A, Naik T, Sun X, Bi D, Malhotra D, Hession CC, Shema R, Gomes M, Li T, Hwang E, Krol A, Kowalczyk M, Peça J, Pan G, Halassa MM, Levin JZ, Fu Z, Feng G. Nature. 2020 Jul;583(7818):819-824. doi: 10.1038/s41586-020-2504-5. Epub 2020 Jul 22. Read PDF »
Multiplex precise base editing in cynomolgus monkeys
Zhang W, Aida T, Del Rosario RCH, Wilde JJ, Ding C, Zhang X, Baloch Z, Huang Y, Tang Y, Li D, Lu H, Zhou Y, Jiang M, Xu D, Fang Z, Zheng Z, Huang Q, Feng G, Yang S. Nat Commun. 2020 May 11;11(1):2325. doi: 10.1038/s41467-020-16173-0. Read PDF »
An Ultra-Sensitive Step-Function Opsin for Minimally Invasive Optogenetic Stimulation in Mice and Macaques
Gong X, Mendoza-Halliday D, Ting JT, Kaiser T, Sun X, Bastos AM, Wimmer RD, Guo B, Chen Q, Zhou Y, Pruner M, Wu CW, Park D, Deisseroth K, Barak B, Boyden ES, Miller EK, Halassa MM, Fu Z, Bi G, Desimone R, Feng G. Neuron. 2020 Jul 8;107(1):38-51.e8. doi: 10.1016/j.neuron.2020.03.032. Epub 2020 Apr 29.
Close-range vocal interaction in the common marmoset (Callithrix jacchus)
Landman R, Sharma J, Hyman JB, Fanucci-Kiss A, Meisner O, Parmar S, Feng G, Desimone R. PLoS One. 2020 Apr 16;15(4):e0227392. doi: 10.1371/journal.pone.0227392. eCollection 2020. Read PDF »
Dysfunction of cortical GABAergic neurons leads to sensory hyper-reactivity in a Shank3 mouse model of ASD
Chen Q, Deister CA, Gao X, Guo B, Lynn-Jones T, Chen N, Wells MF, Liu R, Goard MJ, Dimidschstein J, Feng S, Shi Y, Liao W, Lu Z, Fishell G, Moore CI, Feng G. Nat Neurosci. 2020 Apr;23(4):520-532. doi: 10.1038/s41593-020-0598-6. Epub 2020 Mar 2. Read PDF »
Effects of a patient-derived de novo coding alteration of CACNA1I in mice connect a schizophrenia risk gene with sleep spindle deficits
Ghoshal A, Uygun DS, Yang L, McNally JM, Lopez-Huerta VG, Arias-Garcia MA, Baez-Nieto D, Allen A, Fitzgerald M, Choi S, Zhang Q, Hope JM, Yan K, Mao X, Nicholson TB, Imaizumi K, Fu Z, Feng G, Brown RE, Strecker RE, Purcell SM, Pan JQ. Transl Psychiatry. 2020 Jan 23;10(1):29. doi: 10.1038/s41398-020-0685-1. Read PDF »
Differential excitatory vs inhibitory SCN expression at single cell level regulates brain sodium channel function in neurodevelopmental disorders
Du J, Simmons S, Brunklaus A, Adiconis X, Hession CC, Fu Z, Li Y, Shema R, Møller RS, Barak B, Feng G, Meisler M, Sanders S, Lerche H, Campbell AJ, McCarroll S, Levin JZ, Lal D. Eur J Paediatr Neurol. 2020 Jan;24:129-133. doi: 10.1016/j.ejpn.2019.12.019. Epub 2019 Dec 28.
Shank3 mutation in a mouse model of autism leads to changes in the S-nitroso-proteome and affects key proteins involved in vesicle release and synaptic function
Amal H, Barak B, Bhat V, Gong G, Joughin BA, Wang X, Wishnok JS, Feng G, Tannenbaum SR. Mol Psychiatry. 2020 Aug;25(8):1835-1848. doi: 10.1038/s41380-018-0113-6. Epub 2018 Jul 9. Read PDF »
2019
Combinatorial Targeting of Distributed Forebrain Networks Reverses Noise Hypersensitivity in a Model of Autism Spectrum Disorder
Nakajima M, Schmitt LI, Feng G, Halassa MM. Neuron. 2019 Nov 6;104(3):488-500.e11. doi: 10.1016/j.neuron.2019.09.040. Epub 2019 Oct 21. Read PDF »
A framework for the investigation of rare genetic disorders in neuropsychiatry
Sanders SJ, Sahin M, Hostyk J, Thurm A, Jacquemont S, Avillach P, Douard E, Martin CL, Modi ME, Moreno-De-Luca A, Raznahan A, Anticevic A, Dolmetsch R, Feng G, Geschwind DH, Glahn DC, Goldstein DB, Ledbetter DH, Mulle JG, Pasca SP, Samaco R, Sebat J, Pariser A, Lehner T, Gur RE, Bearden CE. Nat Med. 2019 Oct;25(10):1477-1487. doi: 10.1038/s41591-019-0581-5. Epub 2019 Sep 23. Read PDF »
Efficient generation of Knock-in/Knock-out marmoset embryo via CRISPR/Cas9 gene editing
Kumita W, Sato K, Suzuki Y, Kurotaki Y, Harada T, Zhou Y, Kishi N, Sato K, Aiba A, Sakakibara Y, Feng G, Okano H, Sasaki E. Sci Rep. 2019 Sep 3;9(1):12719. doi: 10.1038/s41598-019-49110-3. Read PDF »
Remotely controlled chemomagnetic modulation of targeted neural circuits
Rao S, Chen R, LaRocca AA, Christiansen MG, Senko AW, Shi CH, Chiang PH, Varnavides G, Xue J, Zhou Y, Park S, Ding R, Moon J, Feng G, Anikeeva P. Nat Nanotechnol. 2019 Oct;14(10):967-973. doi: 10.1038/s41565-019-0521-z. Epub 2019 Aug 19. Read PDF »
Targeting Peripheral Somatosensory Neurons to Improve Tactile-Related Phenotypes in ASD Models
Orefice LL, Mosko JR, Morency DT, Wells MF, Tasnim A, Mozeika SM, Ye M, Chirila AM, Emanuel AJ, Rankin G, Fame RM, Lehtinen MK, Feng G, Ginty DD. Cell. 2019 Aug 8;178(4):867-886.e24. doi: 10.1016/j.cell.2019.07.024. Read PDF »
Anterior cingulate cortex dysfunction underlies social deficits in Shank3 mutant mice
Guo B, Chen J, Chen Q, Ren K, Feng D, Mao H, Yao H, Yang J, Liu H, Liu Y, Jia F, Qi C, Lynn-Jones T, Hu H, Fu Z, Feng G, Wang W, Wu S. Nat Neurosci. 2019 Aug;22(8):1223-1234. doi: 10.1038/s41593-019-0445-9. Epub 2019 Jul 22. Read PDF »
Tmem119-EGFP and Tmem119-CreERT2 Transgenic Mice for Labeling and Manipulating Microglia
Kaiser T, Feng G. eNeuro. 2019 Aug 26;6(4):ENEURO.0448-18.2019. doi: 10.1523/ENEURO.0448-18.2019. Print 2019 Jul/Aug. Read PDF »
A VTA GABAergic Neural Circuit Mediates Visually Evoked Innate Defensive Responses
Zhou Z, Liu X, Chen S, Zhang Z, Liu Y, Montardy Q, Tang Y, Wei P, Liu N, Li L, Song R, Lai J, He X, Chen C, Bi G, Feng G, Xu F, Wang L. Neuron. 2019 Aug 7;103(3):473-488.e6. doi: 10.1016/j.neuron.2019.05.027. Epub 2019 Jun 12. Read PDF »
Atypical behaviour and connectivity in SHANK3-mutant macaques
Zhou Y, Sharma J, Ke Q, Landman R, Yuan J, Chen H, Hayden DS, Fisher JW 3rd, Jiang M, Menegas W, Aida T, Yan T, Zou Y, Xu D, Parmar S, Hyman JB, Fanucci-Kiss A, Meisner O, Wang D, Huang Y, Li Y, Bai Y, Ji W, Lai X, Li W, Huang L, Lu Z, Wang L, Anteraper SA, Sur M, Zhou H, Xiang AP, Desimone R, Feng G, Yang S. Nature. 2019 Jun;570(7761):326-331. doi: 10.1038/s41586-019-1278-0. Epub 2019 Jun 12. Read PDF »
Neuronal deletion of Gtf2i, associated with Williams syndrome, causes behavioral and myelin alterations rescuable by a remyelinating drug
Barak B, Zhang Z, Liu Y, Nir A, Trangle SS, Ennis M, Levandowski KM, Wang D, Quast K, Boulting GL, Li Y, Bayarsaihan D, He Z, Feng G. Nat Neurosci. 2019 May;22(5):700-708. doi: 10.1038/s41593-019-0380-9. Epub 2019 Apr 22. Read PDF »
Abnormal mGluR-mediated synaptic plasticity and autism-like behaviours in Gprasp2 mutant mice
Edfawy M, Guedes JR, Pereira MI, Laranjo M, Carvalho MJ, Gao X, Ferreira PA, Caldeira G, Franco LO, Wang D, Cardoso AL, Feng G, Carvalho AL, Peça J. Nat Commun. 2019 Mar 29;10(1):1431. doi: 10.1038/s41467-019-09382-9. Read PDF »
Lateral orbitofrontal dysfunction in the Sapap3 knockout mouse model of obsessive–compulsive disorder
Lei H, Lai J, Sun X, Xu Q, Feng G. J Psychiatry Neurosci. 2019 Mar 1;44(2):120-131. doi: 10.1503/jpn.180032. Read PDF »
Deep convolutional network for animal sound classification and source attribution using dual audio recordings
Oikarinen T, Srinivasan K, Meisner O, Hyman JB, Parmar S, Fanucci-Kiss A, Desimone R, Landman R, Feng G. J Acoust Soc Am. 2019 Feb;145(2):654. doi: 10.1121/1.5087827. Read PDF »
Two eARCHT3.0 Lines for Optogenetic Silencing of Dopaminergic and Serotonergic Neurons
Krol A, Lopez-Huerta VG, Corey TEC, Deisseroth K, Ting JT, Feng G. Front Neural Circuits. 2019 Feb 1;13:4. doi: 10.3389/fncir.2019.00004. eCollection 2019. Read PDF »
2018
Functional Topography and Development of Inhibitory Reticulothalamic Barreloid Projections
Imaizumi K, Yanagawa Y, Feng G, Lee CC. Front Neuroanat. 2018 Oct 31;12:87. doi: 10.3389/fnana.2018.00087. eCollection 2018. Read PDF »
Thrombospondin receptor α2δ-1 promotes synaptogenesis and spinogenesis via postsynaptic Rac1
Risher WC, Kim N, Koh S, Choi JE, Mitev P, Spence EF, Pilaz LJ, Wang D, Feng G, Silver DL, Soderling SH, Yin HH, Eroglu C. J Cell Biol. 2018 Oct 1;217(10):3747-3765. doi: 10.1083/jcb.201802057. Epub 2018 Jul 27. Read PDF »
Dichotomous parvalbumin interneuron populations in dorsolateral and dorsomedial striatum
Monteiro P, Barak B, Zhou Y, McRae R, Rodrigues D, Wickersham IR, Feng G. J Physiol. 2018 Aug;596(16):3695-3707. doi: 10.1113/JP275936. Epub 2018 Jun 9. Read PDF »
Differential Effects of Deep Brain Stimulation of the Internal Capsule and the Striatum on Excessive Grooming in Sapap3 Mutant Mice
Pinhal CM, van den Boom BJG, Santana-Kragelund F, Fellinger L, Bech P, Hamelink R, Feng G, Willuhn I, Feenstra MGP, Denys D. Biol Psychiatry. 2018 Dec 15;84(12):917-925. doi: 10.1016/j.biopsych.2018.05.011. Epub 2018 May 23.
Combining NGN2 Programming with Developmental Patterning Generates Human Excitatory Neurons with NMDAR-Mediated Synaptic Transmission
Nehme R, Zuccaro E, Ghosh SD, Li C, Sherwood JL, Pietilainen O, Barrett LE, Limone F, Worringer KA, Kommineni S, Zang Y, Cacchiarelli D, Meissner A, Adolfsson R, Haggarty S, Madison J, Muller M, Arlotta P, Fu Z, Feng G, Eggan K. Cell Rep. 2018 May 22;23(8):2509-2523. doi: 10.1016/j.celrep.2018.04.066. Read PDF »
Thalamic Reticular Dysfunction as a Circuit Endophenotype in Neurodevelopmental Disorders
Krol A, Wimmer RD, Halassa MM, Feng G. Neuron. 2018 Apr 18;98(2):282-295. doi: 10.1016/j.neuron.2018.03.021. Read PDF »
Windows of opportunity: timing in neurodevelopmental disorders
Krol A, Feng G. Curr Opin Neurobiol. 2018 Feb;48:59-63. doi: 10.1016/j.conb.2017.10.014. Epub 2017 Nov 7. Read PDF »
2017
Synaptic Targeting and Function of SAPAPs Mediated by Phosphorylation-Dependent Binding to PSD-95 MAGUKs
Zhu J, Zhou Q, Shang Y, Li H, Peng M, Ke X, Weng Z, Zhang R, Huang X, Li SSC, Feng G, Lu Y, Zhang M. Cell Rep. 2017 Dec 26;21(13):3781-3793. doi: 10.1016/j.celrep.2017.11.107. Read PDF »
Alpha2delta-1 in SF1(+) Neurons of the Ventromedial Hypothalamus Is an Essential Regulator of Glucose and Lipid Homeostasis
Felsted JA, Chien CH, Wang D, Panessiti M, Ameroso D, Greenberg A, Feng G, Kong D, Rios M. Cell Rep. 2017 Dec 5;21(10):2737-2747. doi: 10.1016/j.celrep.2017.11.048. Read PDF »
Integrating evolutionary and regulatory information with a multispecies approach implicates genes and pathways in obsessive-compulsive disorder
Noh HJ, Tang R, Flannick J, O’Dushlaine C, Swofford R, Howrigan D, Genereux DP, Johnson J, van Grootheest G, Grünblatt E, Andersson E, Djurfeldt DR, Patel PD, Koltookian M, M Hultman C, Pato MT, Pato CN, Rasmussen SA, Jenike MA, Hanna GL, Stewart SE, Knowles JA, Ruhrmann S, Grabe HJ, Wagner M, Rück C, Mathews CA, Walitza S, Cath DC, Feng G, Karlsson EK, Lindblad-Toh K. Nat Commun. 2017 Oct 17;8(1):774. doi: 10.1038/s41467-017-00831-x. Read PDF »
Genome-wide association analysis identifies 30 new susceptibility loci for schizophrenia
Li Z, Chen J, Yu H, He L, Xu Y, Zhang D, Yi Q, Li C, Li X, Shen J, Song Z, Ji W, Wang M, Zhou J, Chen B, Liu Y, Wang J, Wang P, Yang P, Wang Q, Feng G, Liu B, Sun W, Li B, He G, Li W, Wan C, Xu Q, Li W, Wen Z, Liu K, Huang F, Ji J, Ripke S, Yue W, Sullivan PF, O’Donovan MC, Shi Y. Nat Genet. 2017 Nov;49(11):1576-1583. doi: 10.1038/ng.3973. Epub 2017 Oct 9. Read PDF »
Striatopallidal dysfunction underlies repetitive behavior in Shank3-deficient model of autism
Wang W, Li C, Chen Q, van der Goes MS, Hawrot J, Yao AY, Gao X, Lu C, Zang Y, Zhang Q, Lyman K, Wang D, Guo B, Wu S, Gerfen CR, Fu Z and Feng G. The Journal of clinical investigation. May 2017, 127(5):1978-1990, doi: 10.1172/JCI87997. Read PDF »
SHANK proteins: roles at the synapse and in autism spectrum disorder
Monteiro P and Feng G. Nature Reviews Neuroscience. Mar 2017, 18(3):147-157, doi: 10.1038/nrn.2016.183. Read PDF»
Chd8 mutation leads to autistic-like behaviors and impaired striatal circuits
Platt RJ, Zhou Y, Slaymaker IM, Shetty AS, Weisbach NR, Kim JA, Sharma J, Desai M, Sood S, Kempton HR, Crabtree GR, Feng G and Zhang F. Cell Reports. Apr 2017, 19(2):335-350, doi: 10.1016/j.celrep.2017.03.052. Read PDF »
Animal models for neuropsychiatric disorders: prospects for circuit intervention
Kaiser T, Zhou Y and Feng G. Current Opinion in Neurobiology. Apr 2017, 45:59-65, doi: 10.1016/j.conb.2017.03.010. Read PDF »
2016
A viral strategy for targeting and manipulating interneurons across vertebrate species
Dimidschstein J, Chen Q, Tremblay R, Rogers SL, Saldi GA, Guo L, Xu Q, Liu R, Lu C, Chu J, Grimley JS, Krostag AR, Kaykas A, Avery MC, Rashid MS, Baek M, Jacob AL, Smith GB, Wilson DE, Kosche G, Kruglikov I, Rusielewicz T, Kotak VC, Mowery TM, Anderson SA, Callaway EM, Dasen JS, Fitzpatrick D, Fossati V, Long MA, Noggle S, Reynolds JH, Sanes DH, Rudy B, Feng G, Fishell G. Nature Neuroscience. Dec 2016, 19(12):1743-1749, doi: 10.1038/nn.4430. Read PDF »
Lenihan JA, Saha O, Heimer-McGinn V, Cryan JF, Feng G and Young PW. Molecular Neurobiology. Nov 2016, doi: 10.1007/s12035-016-0261-0. Read PDF »
Direct modulation of GFAP-expressing glia in the arcuate nucleus bi-directionally regulates feeding
Chen N, Sugihara H, Kim J, Fu Z, Barak B, Sur M, Feng G and Han W. Molecular Neurobiology. Oct 2016;5. pii: e18716, doi: 10.7554/eLife.18716. Read PDF »
Opportunities and challenges in modeling human brain disorders in transgenic primates
Jennings CG, Landman R, Zhou Y, Sharma J, Hyman J, Movshon JA, Qiu Z, Roberts AC, Roe AW, Wang X, Zhou H, Wang L, Zhang F, Desimone R and Feng G. Nature Neuroscience. Aug 2016, 19(9):1123-30, doi: 10.1038/nn.4362. Read PDF »
Park J, Yu YP, Zhou CY, Li KW, Wang D, Chang E, Kim DS, Vo B, Zhang X, Gong N, Sharp K, Steward O, Vitko I, Perez-Reyes E, Eroglu C, Barres B, Zaucke F, Feng G and Luo ZD. The Journal of Biological Chemistry. Jun 2016, 291(25):13335-48, doi: 10.1074/jbc.M116.723478. Read PDF »
Optogenetic visualization of presynaptic tonic inhibition of cerebellar parallel fibers
Berglund K, Wen L, Dunbar RL, Feng G and Augustine GJ. The Journal of Neuroscience. May 2016, 36(21):5709-23, doi: 10.1523/JNEUROSCI.4366-15.2016. Read PDF »
Ma Y, Li J, Wang G, Ke Q, Qiu S, Gao L, Wan H, Zhou Y, Xiang AP, Huang Q, Feng G, Zhou Q and Yang S. Scientific Reports. May 2016, 6:25888, doi: 10.1038/srep25888. Read PDF »
Neurobiology of social behavior abnormalities in autism and Williams syndrome
Barak B and Feng G. Nature Neuroscience. Apr 2016, 19(6):647-55, doi: 10.1038/nn.4276. Read PDF »
Thalamic reticular impairment underlies attention deficit in Ptchd1(Y/-) mice
Wells MF, Wimmer RD, Schmitt LI, Feng G and Halassa MM. Nature. Apr 2016; 532(7597):58-63, doi: 10.1038/nature17427. Read PDF »
Optogenetic dissection of ictal propagation in the hippocampal-entorhinal cortex structures
Lu Y, Zhong C, Wang L, Wei P, He W, Huang K, Zhang Y, Zhan Y, Feng G and Wang L. Nature Communications. Mar 2016, 7:10962. doi: 10.1038/ncomms10962. Read PDF »
Adult restoration of Shank3 expression rescues selective autistic-like phenotypes
Mei Y, Monteiro P, Zhou Y, Kim JA, Gao X, Fu Z and Feng G. Nature. Feb 2016, 530(7591):481-4, doi: 10.1038/nature16971. Read PDF »
Impaired dendritic development and memory in Sorbs2 knock-out mice
Zhang Q, Gao X, Li C, Feliciano C, Wang D, Zhou D, Mei Y, Monteiro P, Anand M, Itohara S, Dong X, Fu Z and Feng G. The Journal of Neuroscience. Feb 2016, 36(7):2247-60, doi: 10.1523/JNEUROSCI.2528-15.2016. Read PDF »
Zhou Y, Kaiser T, Monteiro P, Zhang X, Van der Goes MS, Wang D, Barak B, Zeng M, Li C, Lu C, Wells M, Amaya A, Nguyen S, Lewis M, Sanjana N, Zhou Y, Zhang M, Zhang F, Fu Z and Feng G. Neuron. Jan 2016, 89(1):147-62, doi: 10.1016/j.neuron.2015.11.023. Read PDF »
Striatal magnetic resonance spectroscopy abnormalities in young adult SAPAP3 knockout mice
Mintzopoulos D, Gillis TE, Robertson HR, Dalia T, Feng G, Rauch SL and Kaufman MJ. Biological Psychiatry Cognitive Neuroscience and Neuroimaging. Jan 2016, 1(1):39-48, doi: 10.1016/j.bpsc.2015.10.001. Read PDF »
Learning from animal models of obsessive-compulsive disorder
Monteiro P and Feng G. Biological Psychiatry. Jan 2016, 79(1):7-16, doi: 10.1016/j.biopsych.2015.04.020. Read PDF »
2015
Modeling psychiatric disorders for developing effective treatments
Kaiser T and Feng G. Nature Medicine. Sep 2015, 21(9):979-88, doi: 10.1038/nm.3935. Read PDF »
Bosley KS, Botchan M, Bredenoord AL, Carroll D, Charo RA, Charpentier E, Cohen R, Corn J, Doudna J, Feng G, Greely HT, Isasi R, Ji W, Kim JS, Knoppers B, Lanphier E, Li J, Lovell-Badge R, Martin GS, Moreno J, Naldini L, Pera M, Perry AC, Venter JC, Zhang F and Zhou Q. Nature Biotechnology. May 2015, 33(5):478-86, doi: 10.1038/nbt.3227. Read PDF »
Striatal circuits, habits, and implications for obsessive-compulsive disorder
Burguière E, Monteiro P, Mallet L, Feng G and Graybiel AM. Current Opinion in Neurobiology. Feb 2015, 30:59-65, doi: 10.1016/j.conb.2014.08.008. Read PDF »
2014
CRISPR-Cas9 knockin mice for genome editing and cancer modeling
Platt RJ, Chen S, Zhou Y, Yim MJ, Swiech L, Kempton HR, Dahlman JE, Parnas O, Eisenhaure TM, Jovanovic M, Graham DB, Jhunjhunwala S, Heidenreich M, Xavier RJ, Langer R, Anderson DG, Hacohen N, Regev A, Feng G, Sharp PA and Zhang F. Cell. Oct 2014, 159(2):440-55, doi: 10.1016/j.cell.2014.09.014. Read PDF »
Sensory integration in mouse insular cortex reflects GABA circuit maturation
Gogolla N, Takesian AE, Feng G, Fagiolini M and Hensch TK. Neuron. Aug 2014, 83(4):894-905, doi: 10.1016/j.neuron.2014.06.033. Read PDF »
Ting JT, Daigle TL, Chen Q and Feng G. Methods in Molecular Biology. Jun 2014, 1183:221-42, doi: 10.1007/978-1-4939-1096-0_14. Read PDF »
McCarroll SA, Feng G and Hyman SE. Nature Neuroscience. 2014 Jun, 17(6):756-63, doi: 10.1038/nn.3716. Read PDF »
McCarroll SA, Feng G and Hyman SE. Nature Neuroscience. 2014 Jun, 17(6):756-63, doi: 10.1038/nn.3716. Read PDF »
Wan Y, Ade KK, Caffall Z, Ilcim Ozlu M, Eroglu C, Feng G and Calakos N. Biological Psychiatry. Apr 2014, 75(8):623-30, doi: 10.1016/j.biopsych.2013.01.008. Read PDF »
Ting JT and Feng G. Frontiers in Behavioral Neuroscience. Apr 2014, 8:111, doi: 10.3389/fnbeh.2014.00111. Read PDF »
The role of muscle microRNAs in repairing the neuromuscular junction
Valdez G, Heyer MP, Feng G, Sanes JR. PLoS One. Mar 2014, 9(3):e93140, doi: 10.1371/journal.pone.0093140. Read PDF »
Tang R, Noh HJ, Wang D, Sigurdsson S, Swofford R, Perloski M, Duxbury M, Patterson EE, Albright J, Castelhano M, Auton A, Boyko AR, Feng G, Lindblad-Toh K and Karlsson EK. Genome Biology. Mar 2014, 15(3):R25, doi: 10.1186/gb-2014-15-3-r25. Read PDF »
Selective activation of cholinergic basal forebrain neurons induces immediate sleep-wake transitions
Han Y, Shi YF, Xi W, Zhou R, Tan ZB, Wang H, Li XM, Chen Z, Feng G, Luo M, Huang ZL, Duan S and Yu YQ. Current Biology. Mar 2014, 24(6):693-8, doi: 10.1016/j.cub.2014.02.011. Read PDF »
Flow of cortical activity underlying a tactile decision in mice
Guo ZV, Li N, Huber D, Ophir E, Gutnisky D, Ting JT, Feng G and Svoboda K. Neuron. Jan 2014, 81(1):179-94, doi: 10.1016/j.neuron.2013.10.020. Read PDF »
2013
Next-generation transgenic mice for optogenetic analysis of neural circuits
Asrican B, Augustine GJ, Berglund K, Chen S, Chow N, Deisseroth K, Feng G, Gloss B, Hira R, Hoffmann C, Kasai H, Katarya M, Kim J, Kudolo J, Lee LM, Lo SQ, Mancuso J, Matsuzaki M, Nakajima R, Qiu L, Tan G, Tang Y, Ting JT, Tsuda S, Wen L, Zhang X and Zhao S. Frontiers in Neural Circuits. Nov 2013, 7:160, doi: 10.3389/fncir.2013.00160. Read PDF »
Ting JT and Feng G. Behavioural Brain Research. Oct 2013, 255:3-18. doi: 10.1016/j.bbr.2013.02.037. Read PDF »
Kolisnyk B, Guzman MS, Raulic S, Fan J, Magalhães AC, Feng G, Gros R, Prado VF and Prado MA. The Journal of Neuroscience. Jun 2013, 33(25):10427-38, doi: 10.1523/JNEUROSCI.0395-13.2013. Read PDF »
Optogenetic stimulation of lateral orbitofronto-striatal pathway suppresses compulsive behaviors
Burguière E, Monteiro P, Feng G and Graybiel AM. Science. Jun 2013, 340(6137):1243-6, doi: 10.1126/science.1232380. Read PDF »
Kumar S, Black SJ, Hultman R, Szabo ST, DeMaio KD, Du J, Katz BM, Feng G, Covington HE 3rd and Dzirasa K. The Journal of Neuroscience. Jan 2013, 33(3):1116-29, doi: 10.1523/JNEUROSCI.0092-12.2013. Read PDF »
2012
Monoacylglycerol lipase is a new therapeutic target for Alzheimer’s disease
Chen R, Zhang J, Wu Y, Wang D, Feng G, Tang Y, Teng Z, and Chen C. Cell Reports. Dec 2012, 2(5): 1329–1339, doi: 10.1016/j.celrep.2012.09.030. Read PDF »
Peça J and Feng G. Current Opinion in Neurobiology. Oct 2012, 22(5):866-72, doi: 10.1016/j.conb.2012.02.015. Read PDF »
Imaging neural activity using Thy1-GCaMP transgenic mice
Chen Q, Cichon J, Wang W, Qiu L, Lee SJ, Campbell NR, Destefino N, Goard MJ, Fu Z, Yasuda R, Looger LL, Arenkiel BR, Gan WB and Feng G. Neuron. Oct 2012, 76(2):297-308, doi: 10.1016/j.neuron.2012.07.011. Read PDF »
Normal midbrain dopaminergic neuron development and function in miR-133b mutant mice
Heyer MP, Pani AK, Smeyne RJ, Kenny PJ, Feng G. The Journal of Neuroscience. Aug 2012, 32(32):10887-94, doi: 10.1523/JNEUROSCI.1732-12.2012. Read PDF »
Ting JT, Peça J and Feng G. Annual Review of Neuroscience. Jul 2012, 35:49-71, doi: 10.1146/annurev-neuro-062111-150442. Read PDF »
Intersectional Cre driver lines generated using split-Intein mediated split-Cre reconstitution
Wang P, Chen C, Sakurai K, Han B, He Z, Feng G and Wanga F. Scientific Reports. Jul 2012, 2: 497, doi:  10.1038/srep00497. Read PDF »
A Transcription Activator-Like Effector (TALE) Toolbox for Genome Engineering
Sanjana N, Cong L, Zhou Y, Cunniff M, Feng G and Zhang F. Nature Protocols. Jan 2012, 7(1): 171–192, doi:  10.1038/nprot.2011.431. Read PDF »
2011
Imaging synaptic inhibition with the genetically encoded chloride indicator Clomeleon
Berglund K, Kuner T, Feng G and Augustine GJ. Cold Spring Harbor Protocols. Dec 2011, 2011(12):1492-7, doi: 10.1101/pdb.prot066985. Read PDF »
Ting JT and Feng G. Current Opinion in Neurobiology. Dec 2011, 21(6):842-8, doi: 10.1016/j.conb.2011.04.010. Read PDF »
Sapap3 deletion causes mGluR5-dependent silencing of AMPAR synapses
Wan Y, Feng G and Calakos N. The Journal of Neuroscience. Nov 2011, 31(46):16685-91, doi: 10.1523/JNEUROSCI.2533-11.2011. Read PDF »
Sustained axon regeneration induced by co-deletion of PTEN and SOCS3
Sun F, Park KK, Belin S, Wang D, Lu T, Chen G, Zhang K, Yeung C, Feng G, Yankner BA and He Z. Nature. Nov 2011, 6;480(7377):372-5, doi: 10.1038/nature10594. Read PDF »
Unfolding neurodevelopmental disorders: found in translation
Ting JT and Feng G. Nature Medicine. Nov 2011, 17(11):1352-3, doi: 10.1038/nm.2553. Read PDF »
Peça J, Ting J and Feng G. Cell. Oct 2011, 147(3):706, 706.e1, doi: 10.1016/j.cell.2011.10.015. Read PDF »
Cell-type specific optogenetic mice for dissecting neural circuitry function
Zhao S, Ting T, Atallah H, Qiu L, Tan J, Gloss B, Augustine G, Deisseroth K, Luo M, Graybiel A and Feng G. Nature Methods. Sep 2011, 8(9): 745–752. Read PDF »
Peça J and Feng G. Nature. Sep 2011, 477(7363):165-6, doi: 10.1038/477165a. Read PDF »
Halassa MM, Siegle JH, Ritt JT, Ting JT, Feng G and Moore CI. Nature Neuroscience. Jul 2011, 14(9):1118-20, doi: 10.1038/nn.2880. Read PDF »
Sapap3 deletion anomalously activates short-term endocannabinoid-mediated synaptic plasticity
Chen M, Wan Y, Ade K, Ting J, Feng G and Calakos N. The Journal of Neuroscience. Jun 2011, 31(26):9563-73, doi: 10.1523/JNEUROSCI.1701-11.2011. Read PDF »
Annual Research Review: Transgenic mouse models of childhood-onset psychiatric disorders
Robertson HR and Feng G. Journal of Child Psychology and Psychiatry. Apr 2011, 52(4):442-75, doi: 10.1111/j.1469-7610.2011.02380.x. Read PDF »
Shank3 mutant mice display autistic-like behaviours and striatal dysfunction
Peça J, Feliciano C, Ting JT, Wang W, Wells MF, Venkatraman TN, Lascola CD, Fu Z and Feng G. Nature. Apr 2011, 28;472(7344):437-42, doi: 10.1038/nature09965. Read PDF »
Ren J, Qin C, Hu F, Tan J, Qiu L, Zhao S, Feng G and Luo M. Neuron. Feb 2011, 69(3):445-52, doi: 10.1016/j.neuron.2010.12.038. Read PDF »
Pulse labeling and long-term tracing of newborn neurons in the adult subgranular zone
Cheng X, Li Y, Huang Y, Feng X, Feng G and Xiong ZQ. Cell Research. Feb 2011, 21(2):338-49, doi: 10.1038/cr.2010.141. Read PDF »
2010
Zhao S, Zhou Y, Gross J, Miao P, Qiu L, Wang D, Chen Q and Feng G. PLoS One. Sep 2010, 5(9). pii: e12506, doi: 10.1371/journal.pone.0012506. Read PDF »
Progressive NKCC1-dependent neuronal chloride accumulation during neonatal seizures
Dzhala VI, Kuchibhotla KV, Glykys JC, Kahle KT, Swiercz WB, Feng G, Kuner T, Augustine GJ, Bacskai BJ and Staley KJ. The Journal of Neuroscience. Sep 2010, 30(35):11745-61, doi: 10.1523/JNEUROSCI.1769-10.2010. Read PDF »
Thyagarajan S, van Wyk M, Lehmann K, Löwel S, Feng G and Wässle H. The Journal of neuroscience. Jun 2010, 30(26):8745-58, doi: 10.1523/JNEUROSCI.4417-09.2010. Read PDF »
2009
Glykys J, Dzhala VI, Kuchibhotla KV, Feng G, Kuner T, Augustine G, Bacskai BJ and Staley KJ. Neuron. Sep 2009, 63(5): 657–672, doi: 10.1016/j.neuron.2009.08.022. Read PDF »
Genetic perturbation of postsynaptic activity regulates synapse elimination in developing cerebellum
Lorenzetto E, Caselli L, Feng G, Yuan W, Nerbonne JM, Sanes JR and Buffelli M. Proceedings of the National Academy of Sciences of the United States of America. Sep 2009, 106(38):16475-80, doi: 10.1073/pnas.0907298106. Read PDF »
Downregulation of NR3A-containing NMDARs is required for synapse maturation and memory consolidation
Roberts AC, DÃez-GarcÃa J, Rodriguiz RM, López IP, Luján R, MartÃnez-Turrillas R, Picó E, Henson MA, Bernardo DR, Jarrett TM, Clendeninn DJ, López-Mascaraque L, Feng G, Lo DC, Wesseling JF, Wetsel WC, Philpot BD and Pérez-Otaño I. Neuron. Aug 2009, 63(3):342-56, doi: 10.1016/j.neuron.2009.06.016. Read PDF »
Nguyen D, Deng P, Matthews EA, Kim DS, Feng G, Dickenson AH, Xu ZC and Luo ZD. Molecular Pain. Feb 2009, 5:6, doi: 10.1186/1744-8069-5-6. Read PDF »
2008
Glutamatergic synaptic dysfunction and obsessive-compulsive disorder
Ting JT and Feng G. Current Chemical Genomics. Dec 2008, 2: 62–75, doi: 10.2174/1875397300802010062. Read PDF »
Imaging synaptic inhibition throughout the brain via genetically targeted Clomeleon
Berglund K, Schleich W, Wang H, Feng G, Hall WC, Kuner T and Augustine GJ. Brain Cell Biology. Aug 2008, 36(1-4):101-18, doi: 10.1007/s11068-008-9031-x. Read PDF »
Improved expression of halorhodopsin for light-induced silencing of neuronal activity
Zhao S, Cunha C, Zhang F, Liu Q, Gloss B, Deisseroth K, Augustine GJ and Feng G. Brain Cell Biology. Aug 2008, 36(1-4):141-54, doi: 10.1007/s11068-008-9034-7. Read PDF »
Single-neuron labeling with inducible Cre-mediated knockout in transgenic mice
Young P, Qiu L, Wang D, Zhao S, Gross J and Feng G. Nature Neuroscience. Jun 2008, 11(6):721-8, doi: 10.1038/nn.2118. Read PDF »
2007
Cortico-striatal synaptic defects and OCD-like behaviours in Sapap3-mutant mice
Welch JM, Lu J, Rodriguiz RM, Trotta NC, Peca J, Ding JD, Feliciano C, Chen M, Adams JP, Luo J, Dudek SM, Weinberg RJ, Calakos N, Wetsel WC and Feng G. Nature. Aug 2007, 448(7156):894-900, doi: 10.1038/nature06104. Read PDF »
Arenkiel BR, Peca J, Davison IG, Feliciano C, Deisseroth K, Augustine GJ, Ehlers MD and Feng G. Neuron. Apr 2007 Apr, 54(2):205-18, doi: 10.1016/j.neuron.2007.03.005. Read PDF »
Next-generation optical technologies for illuminating genetically targeted brain circuits
Deisseroth K, Feng G, Majewska AK, Miesenböck G, Ting A and Schnitzer MJ. The Journal of Neuroscience. Oct 2006, 26(41):10380-6, doi: 10.1523/JNEUROSCI.3863-06.2006. Read PDF »
Lu Z, Je HS, Young P, Gross J, Lu B and Feng G. The Journal of Cell Biology. Jun 2007, 177(6):1077-89, doi: 10.1083/jcb.200610060. Read PDF »
The histone deacetylase HDAC4 connects neural activity to muscle transcriptional reprogramming
Cohen TJ, Waddell DS, Barrientos T, Lu Z, Feng G, Cox GA, Bodine SC and Yao TP. The Journal of Biological Chemistry. Nov 2007, 282(46):33752-9, doi: 10.1074/jbc.M706268200. Read PDF »
2006
Calcium channel α2δ1 subunit mediates spinal hyperexcitability in pain modulation
Li C, Zhang X, Matthews E, Li K, Kurwa A, Boroujerdi A, Gross J, Gold MS, Dickenson AH, Feng G and Luo D. Pain. Nov 2006, 125(1-2): 20–34, doi: 10.1016/j.pain.2006.04.022. Read PDF »
Dynamic remodeling of dendritic arbors in GABAergic interneurons of adult visual cortex
Lee WA, Huang H, Feng G, Sanes JR, Brown EN, So PT and Nedivi E. PLoS Biology. Feb 2006, 4(2): e29, doi:  10.1371/journal.pbio.0040029. Read PDF »
Imaging synaptic inhibition in transgenic mice expressing the chloride indicator, Clomeleon
Berglund K, Schleich W, Krieger P, Loo LS, Wang D, Cant NB, Feng G, Augustine GJ and Kuner T. Brain Cell Biology. Dec 2006, 35(4-6): 207–228, doi: 10.1007/s11068-008-9019-6. Read PDF »
In vivo imaging of juxtaglomerular neuron turnover in the mouse olfactory bulb
Mizrahi A1, Lu J, Irving R, Feng G and Katz LC. Proceedings of the National Academy of Sciences of the United States of America. Feb 2006, 103(6):1912-7, doi: 10.1073/pnas.0506297103. Read PDF »
Duebel J, Haverkamp S, Schleich W, Feng G, Augustine GJ, Kuner T and Euler T. Neuron. Jan 2006, 49(1):81-94,  doi: 10.1016/j.neuron.2005.10.035. Read PDF »
2005
Demyanenko GP, Schachner M, Anton E, Schmid R, Feng G, Sanes J and Maness PF. Neuron. Oct 2004, 44(3):423-37, 10.1016/j.neuron.2004.10.016. Read PDF »
NX1 is a perisynaptic Schwann cell specific E3 ubiquitin ligase that interacts with ErbB2
Young P, Nie J, Wang X, McGlade CJ, Rich MM and Feng G. Molecular and Cellular Neurosciences. Oct 2005, 30(2):238-48, 10.1016/j.mcn.2005.07.015. Read PDF »
Ubiquilin-1 regulates nicotine-induced up-regulation of neuronal nicotinic acetylcholine receptors
Ficklin MB, Zhao S and Feng G. The Journal of Biological Chemistry. Oct 2005, 280(40):34088-95, doi: 10.1074/jbc.M506781200. Read PDF »
Bas Orth C, Vlachos A, Del Turco D, Burbach GJ, Haas CA, Mundel P, Feng G, Frotscher M and Deller T. The Journal of Comparative Neurology. Jul 2005, 487(3):227-39, doi: 10.1002/cne.20539. Read PDF »
Haverkamp S, Wässle H, Duebel J, Kuner T, Augustine GJ, Feng G and Euler T. The Journal of Neuroscience. Jun 2005, 25(22):5438-45, doi: 10.1523/JNEUROSCI.1117-05.2005. Read PDF »
2004
Labeling neurons in vivo for morphological and functional studies
Young P and Feng G. Current Opinion in Neurobiology. Oct 2004, 14(5):642-6, doi: 10.1016/j.conb.2004.08.007. Read PDF »
Welch JM, Wang D and Feng G. The Journal of Comparative Neurology. Apr 2004, 472(1):24-39, doi: 10.1002/cne.20060. Read PDF »
PSD93 regulates synaptic stability at neuronal cholinergic synapses
Parker MJ, Zhao S, Bredt DS, Sanes JR and Feng G. The Journal of Neuroscience. Jan 2004, 24(2):378-88, 10.1523/JNEUROSCI.3865-03.2004. Read PDF »
2003
Functional characterization of a neuropeptide F-like receptor from Drosophila melanogaste
Feng G, Reale V, Chatwin H, Kennedy K, Venard R, Ericsson C, Yu K, Evans PD and Hall LM. The European Journal of Neuroscience. Jul 2003, 18(2):227-38. Read PDF »
Genetic evidence that relative synaptic efficacy biases the outcome of synaptic competition
Buffelli M, Burgess RW, Feng G, Lobe CG, Lichtman JW and Sanes JR. Nature. Jul 2003, 424(6947):430-4, doi: 10.1038/nature01844. Read PDF »
Postsynaptic requirement for Abl kinases in assembly of the neuromuscular junction
Finn AJ, Feng G and Pendergast AM. Nature Neuroscience. Jul 2003, 6(7):717-23, doi: 10.1038/nn1071. Read PDF »
Gan WB, Kwon E, Feng G, Sanes JR and Lichtman JW. Nature Neuroscience. Sep 2003, 6(9):956-60, doi: 10.1038/nn1115. Read PDF »
2002
Long-term in Vivo imaging of experience-dependent synaptic plasticity in adult cortex
Trachtenberg J, Chen BE, Knott GW, Feng G, Sanes JR, Welker E and Svoboda K. Nature. Dec 2002, 420 (6917), 788-794, doi: 10.1038/nature01273. Read PDF »
2001
Asynchronous synapse elimination in neonatal motor units: studies using GFP transgenic mice
Keller-Peck CR, Walsh MK, Gan WB, Feng G, Sanes JR and Lichtman JW. Neuron. Aug 2001, 31(3):381-94, doi: 10.1016/S0896-6273(01)00383-X. Read PDF »
Keller-Peck CR, Feng G, Sanes JR, Yan Q, Lichtman JW and Snider WD. The Journal of Neuroscience. Aug 2001, 21(16):6136-46. Read PDF »
Gephyrin-independent clustering of postsynaptic GABA(A) receptor subtypes
Kneussel M, Brandstätter JH, Gasnier B, Feng G, Sanes JR and Betz H. Molecular and Cellular Neurosciences. Jun 2001, 17(6):973-82, doi: 10.1006/mcne.2001.0983. Read PDF »
2000
Imaging neuronal subsets in transgenic mice expressing multiple spectral variants of GFP
Feng G, Mellor RH, Bernstein M, Keller-Peck C, Nguyen QT, Wallace M, Nerbonne JM, Lichtman JW, Sanes JR. Neuron. Oct 2000, 28(1):41-51. Read PDF »
Butler MH, Hayashi A, Ohkoshi N, Villmann C, Becker CM, Feng G, De Camilli P and Solimena M. Neuron. May 2000, 26(2):307-12. Read PDF »
Roles for ephrins in positionally selective synaptogenesis between motor neurons and muscle fibers
Feng G, Laskowski MB, Feldheim DA, Wang H, Lewis R, Frisen J, Flanagan JG and Sanes JR. Neuron. Feb 2000, 5(2):295-306. Read PDF »
1999
Feng G, Krejci E, Molgo J, Cunningham JM, Massoulié J and Sanes JR. The Journal of Cell Biology. Mar 1999, 144(6):1349-60. Read PDF »
Synapse formation by hippocampal neurons from agrin-deficient mice
Serpinskaya AS, Feng G, Sanes JR and Craig AM. Developmental Biology. Jan 1999, 205(1):65-78, doi: 10.1006/dbio.1998.9112. Read PDF »
1998
Dual requirement for gephyrin in glycine receptor clustering and molybdoenzyme activity
Feng G, Tintrup H, Kirsch J, Nichol MC, Kuhse J, Betz H and Sanes JR. Science. Nov 1998, 282(5392):1321-4. Read PDF »
Feng G, Steinbach JH and Sanes JR. The Journal of Neuroscience. Jun 1998, 18(11):4166-76. Read PDF »
Eberl DF, Ren D, Feng G, Lorenz LJ, Van Vactor D and Hall LM. Genetics. Mar 1998, 148(3):1159-69. Read PDF »
1997
Ettinger AJ, Feng G and Sanes JR. J Biol Chem. Dec 1997, 272(51):32534-8. Read PDF »
1996
Cloning and functional characterization of a novel dopamine receptor from Drosophila melanogaster
Feng G, Hannan F, Reale V, Hon YY, Kousky CT, Evans PD and Hall LM. The Journal of Neuroscience. Jun 1996, 16(12):3925-33. Read PDF »
1995
Zheng W, Feng G, Ren D, Eberl DF, Hannan F, Dubald M and Hall LM. The Journal of Neuroscience. Feb 1995, 15(2):1132-43. Read PDF »
Feng G, Deák P, Chopra M and Hall LM. Cell. Sep 1995, 82(6):1001-11. Read PDF »
Feng G, Deák P, Kasbekar DP, Gil DW and Hall LM. Genetics. Apr 1995, 139(4):1679-88. Read PDF »
1992
Murakami K, Feng G and Chen SG. The Journal of Pharmacology and Experimental Therapeutics. Oct 1992, 264(2):757-61. Read PDF »